Intended for Healthcare Professionals

REVERSE-IT is a Phase 3 study for the reversal of the antiplatelet effects of ticagrelor with bentracimab

Intended for Healthcare Professionals

REVERSE-IT is a Phase 3 study for the reversal of the antiplatelet effects of ticagrelor with bentracimab

BENTRACIMAB

A novel monoclonal antibody designed to reverse the antiplatelet activity of ticagrelor

ENROLLING PATIENTS

  • Patients who present with uncontrolled major or life-threatening bleeding
  • Patient who require urgent surgery or invasive procedure

STUDY SUMMARY

Approximately 200 patients will be enrolled from approximately 200 centers in North America, Europe, and Asia-Pacific regions, including mainland China. Patients with reported use of ticagrelor within the prior 3 days who require urgent ticagrelor reversal will be eligible for enrollment. These populations will be enrolled based on separate inclusion criteria.

STUDY LOCATIONS:

Please select a location to see sites near you

Algemeen Stedelijk Ziekenhuis (ASZ) Study Center Cardiology

Aalst, East Flanders, Belgium
August 2, 2021/by eallison

Ascension St. John Clinical Research Institute

Tulsa, Oklahoma
August 2, 2021/by eallison

Assistance Publique-Hopitaux de Paris (AP-HP) Pitie-Salpetriere Hospital

Paris, France
August 2, 2021/by ehennes

ASST Monza Ospedale San Gerardo Terapia Intensiva Neurochirurgica

Monza, Italy
April 21, 2022/by eallison

AZ Sint-Jan Brugge-Oostende AV Poli Cardiologie

Brugge, Belgium
August 2, 2021/by eallison

Baptist Medical Center

Jacksonville, Florida
July 14, 2021/by eallison

Barrow Brain and Spine

Phoenix, Arizona
July 14, 2021/by eallison

Cardiocentro Ticino

Lugano, Switzerland
July 30, 2021/by ehennes

Centre intégré universitaire de santé et de services sociaux du Nord-de-l’lle-de-Montréal (CIUSSS NIM)/Hopital du Sacré-Coeur-de-Montréal

Montreal, Quebec, Canada
April 21, 2022/by eallison

CHRU de Tours – Hopital Trousseau Service de Cardiologie-USCI 2 eme etage

Tours, France
August 2, 2021/by ehennes

CHU de Lille Service USIC, Institut Coeur Poumon

Lille Cedex, France
August 2, 2021/by ehennes

CHU de Poitiers, Centre Cardio-Vasculaire

Poitiers, France
August 2, 2021/by ehennes

Complejo Hospitalario Universitario A Coruna

A Coruña, Spain
July 30, 2021/by ehennes

Cox Medical Centers

Springfield, Missouri
August 2, 2021/by eallison

Crozer Chester Medical Center

Upland, Pennsylvania
August 2, 2021/by eallison

Duke Heart Center At Southeastern Health

Lumberton, North Carolina
April 21, 2022/by eallison

East and North Hertfordshire, NHS Trust, Lister Cardiac Research Office, Cardiology Green Zone, Lister Hospital

Stevenage, Hertfordshire, United Kingdom
July 30, 2021/by ehennes

Foothills Medical Centre

Calgary, Alberta, Canada
August 2, 2021/by ehennes

Hamilton Health Sciences Centre

Hamilton, Ontario, Canada
August 2, 2021/by ehennes

Henry Ford Hospital

Detroit, Michigan
April 21, 2022/by eallison

Hospital Universitario 12 de Octubre, Residencia general

Madrid, Spain
July 30, 2021/by ehennes

Hospital Universitario Vall d’Hebron

Barcelona, Spain
July 30, 2021/by ehennes

Hospital Universitario Vírgen de la Victoria

Málaga, Spain
July 30, 2021/by ehennes

Hospital Universitario Virgen Macarena

Sevilla, Spain
July 30, 2021/by ehennes

Institut universitaire de cardiologie et de pneumologie de Quebec – Universite Laval

Quebec, Canada
August 2, 2021/by ehennes

Intercoastal Medical Group

Sarasota, Florida
April 21, 2022/by eallison

Istituto Clinico Humanitas UO Cardiologia Clinica e Interventistica

Rozzano, Italy
April 21, 2022/by eallison

Jessa Hospital Hartcentrum Hasselt Research Center

Hasselt, Belgium
August 2, 2021/by eallison

JPS Health Network

Fort Worth, Texas
April 21, 2022/by eallison

Kingston Health Sciences Centre

Kingston, Ontario, Canada
August 2, 2021/by ehennes

Klinik Ottakring 3rd Med Dept, Cardiology and Intensive Care Medicine

Wien, Austria
April 21, 2022/by eallison

Klinikum Ludwigshafen Clinic for Cardiology, Pneumology, Angiology and Internal Intensive Care Medicine

Ludwigshafen, Germany
April 21, 2022/by eallison

Klinische Abteilung für Innere Medizin 3 Universitätsklinikum St. Pölten

Graz, Austria
April 21, 2022/by eallison

Mayo Clinic

Jacksonville, Florida
April 21, 2022/by eallison

Medisch Spectrum Twente

Enschede, Netherlands
April 21, 2022/by eallison

MedStar Health Research Institute

Washington, District of Columbia
July 30, 2021/by eallison

Montréal Heart Institute

Montréal, Quebec, Canada
August 2, 2021/by ehennes

North Kansas City Hospital

North Kansas City, Missouri
August 2, 2021/by eallison

Oakville Trafalgar Memorial Hospital

Oakville, Ontario, Canada
August 2, 2021/by ehennes

Region Uppsala, Akademiska Hospital Cardio and Pulmonary Medicine and Clinical Physiology

Uppsala, Sweden
July 30, 2021/by ehennes

Saint John Regional Hospital

Saint John, New Brunswick, Canada
August 2, 2021/by ehennes

Sanford Medical Center Fargo

Fargo, North Dakota
August 2, 2021/by eallison

Sheffield Teaching Hospitals, NHS Foundation Trust, Northern General Hospital

Sheffield, United Kingdom
July 30, 2021/by ehennes

St Antonius Hospital

Nieuwegein, Netherlands
August 2, 2021/by ehennes

St. Boniface Hospital

Winnipeg, Manitoba, Canada
April 21, 2022/by eallison

St. Michael’s Hospital, Unity Health Toronto

Toronto, Ontario, Canada
August 2, 2021/by ehennes

St. Paul’s Hospital

Vancouver, British Columbia, Canada
April 21, 2022/by eallison

Toronto General Hospital

Toronto, Ontario, Canada
August 2, 2021/by ehennes

Universitatsspital Basel Department of Cardiology

Basel, Switzerland
April 21, 2022/by eallison

University Hospital Antwerp Cardiology Department – Clinical Trials

Edegem, Belgium
August 2, 2021/by eallison

University Hospital Leuven, Universitair Ziekenhuis Leuven Dienst Bloedings- en Vaatziekten

Leuven, Belgium
August 2, 2021/by eallison

University of Florida Health, Jacksonville

Jacksonville, Florida
July 14, 2021/by eallison

University of Iowa Hospitals and Clinics

Iowa City, Iowa
July 14, 2021/by eallison

University of Kentucky

Lexington, Kentucky
July 30, 2021/by eallison

University of Ottawa Heart Institute

Ottawa, Ontario, Canada
August 2, 2021/by ehennes

University of Toronto

Toronto, Canada
July 14, 2021/by eallison

York PCI Group, Inc.

Newmarket, Ontario, Canada
August 2, 2021/by ehennes

Ziekenhuis Oost-Limburg Study Center Intensive Care

Genk, Limburg, Belgium
August 2, 2021/by eallison