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Intended for Healthcare Professionals
REVERSE-IT is a Phase 3 study for the reversal of the antiplatelet effects of ticagrelor with bentracimab
Link to: Document Library
DOCUMENT LIBRARY
Access investigator resource library, including trial protocols & amendments, pharmacy manuals, regulatory templates source documents and more.
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CLINICIAN VIGNETTES
Are you in cardiology, hematology or another specialized field? Access interviews with various clinicians whose practice could bring them in contact with patients who may warrant referral to the REVERSE-IT trial.
Link to: Newsroom
NEWSROOM
Stay up to date with the latest trial newsletters, webinars and press releases
BENTRACIMAB
A novel monoclonal antibody designed to reverse the antiplatelet activity of ticagrelor
ENROLLING PATIENTS
- Patients who present with uncontrolled major or life-threatening bleeding
- Patient who require urgent surgery or invasive procedure
STUDY SUMMARY
Approximately 200 patients will be enrolled from approximately 200 centers in North America, Europe, and Asia-Pacific regions, including mainland China. Patients with reported use of ticagrelor within the prior 3 days who require urgent ticagrelor reversal will be eligible for enrollment. These populations will be enrolled based on separate inclusion criteria.
STUDY LOCATIONS:
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All 58 /Arizona 0 /Austria 0 /Belgium 0 /Canada 15 /Florida 4 /France 0 /Germany 0 /Global 42 /Iowa 1 /Italy 0 /Kentucky 0 /Michigan 1 /Missouri 0 /Netherlands 0 /North Carolina 0 /North Dakota 0 /Oklahoma 0 /Pennsylvania 0 /Spain 0 /Sweden 0 /Switzerland 0 /Texas 0 /United Kingdom 0 /United States 16 /Washington D.C. 0
Algemeen Stedelijk Ziekenhuis (ASZ) Study Center Cardiology
Aalst, East Flanders, Belgium
August 2, 2021/by eallisonAscension St. John Clinical Research Institute
Tulsa, Oklahoma
August 2, 2021/by eallisonAssistance Publique-Hopitaux de Paris (AP-HP) Pitie-Salpetriere Hospital
Paris, France
August 2, 2021/by ehennesASST Monza Ospedale San Gerardo Terapia Intensiva Neurochirurgica
Monza, Italy
April 21, 2022/by eallisonAZ Sint-Jan Brugge-Oostende AV Poli Cardiologie
Brugge, Belgium
August 2, 2021/by eallisonBaptist Medical Center
Jacksonville, Florida
July 14, 2021/by eallisonBarrow Brain and Spine
Phoenix, Arizona
July 14, 2021/by eallisonCardiocentro Ticino
Lugano, Switzerland
July 30, 2021/by ehennesCentre intégré universitaire de santé et de services sociaux du Nord-de-l’lle-de-Montréal (CIUSSS NIM)/Hopital du Sacré-Coeur-de-Montréal
Montreal, Quebec, Canada
April 21, 2022/by eallisonCHRU de Tours – Hopital Trousseau Service de Cardiologie-USCI 2 eme etage
Tours, France
August 2, 2021/by ehennesCHU de Lille Service USIC, Institut Coeur Poumon
Lille Cedex, France
August 2, 2021/by ehennesCHU de Poitiers, Centre Cardio-Vasculaire
Poitiers, France
August 2, 2021/by ehennesComplejo Hospitalario Universitario A Coruna
A Coruña, Spain
July 30, 2021/by ehennesCox Medical Centers
Springfield, Missouri
August 2, 2021/by eallisonCrozer Chester Medical Center
Upland, Pennsylvania
August 2, 2021/by eallisonDuke Heart Center At Southeastern Health
Lumberton, North Carolina
April 21, 2022/by eallisonEast and North Hertfordshire, NHS Trust, Lister Cardiac Research Office, Cardiology Green Zone, Lister Hospital
Stevenage, Hertfordshire, United Kingdom
July 30, 2021/by ehennesFoothills Medical Centre
Calgary, Alberta, Canada
August 2, 2021/by ehennesHamilton Health Sciences Centre
Hamilton, Ontario, Canada
August 2, 2021/by ehennesHenry Ford Hospital
Detroit, Michigan
April 21, 2022/by eallisonHospital Universitario 12 de Octubre, Residencia general
Madrid, Spain
July 30, 2021/by ehennesHospital Universitario Vall d’Hebron
Barcelona, Spain
July 30, 2021/by ehennesHospital Universitario Vírgen de la Victoria
Málaga, Spain
July 30, 2021/by ehennesHospital Universitario Virgen Macarena
Sevilla, Spain
July 30, 2021/by ehennesInstitut universitaire de cardiologie et de pneumologie de Quebec – Universite Laval
Quebec, Canada
August 2, 2021/by ehennesIntercoastal Medical Group
Sarasota, Florida
April 21, 2022/by eallisonIstituto Clinico Humanitas UO Cardiologia Clinica e Interventistica
Rozzano, Italy
April 21, 2022/by eallisonJessa Hospital Hartcentrum Hasselt Research Center
Hasselt, Belgium
August 2, 2021/by eallisonJPS Health Network
Fort Worth, Texas
April 21, 2022/by eallisonKingston Health Sciences Centre
Kingston, Ontario, Canada
August 2, 2021/by ehennesKlinik Ottakring 3rd Med Dept, Cardiology and Intensive Care Medicine
Wien, Austria
April 21, 2022/by eallisonKlinikum Ludwigshafen Clinic for Cardiology, Pneumology, Angiology and Internal Intensive Care Medicine
Ludwigshafen, Germany
April 21, 2022/by eallisonKlinische Abteilung für Innere Medizin 3 Universitätsklinikum St. Pölten
Graz, Austria
April 21, 2022/by eallisonMayo Clinic
Jacksonville, Florida
April 21, 2022/by eallisonMedisch Spectrum Twente
Enschede, Netherlands
April 21, 2022/by eallisonMedStar Health Research Institute
Washington, District of Columbia
July 30, 2021/by eallisonMontréal Heart Institute
Montréal, Quebec, Canada
August 2, 2021/by ehennesNorth Kansas City Hospital
North Kansas City, Missouri
August 2, 2021/by eallisonOakville Trafalgar Memorial Hospital
Oakville, Ontario, Canada
August 2, 2021/by ehennesRegion Uppsala, Akademiska Hospital Cardio and Pulmonary Medicine and Clinical Physiology
Uppsala, Sweden
July 30, 2021/by ehennesSaint John Regional Hospital
Saint John, New Brunswick, Canada
August 2, 2021/by ehennesSanford Medical Center Fargo
Fargo, North Dakota
August 2, 2021/by eallisonSheffield Teaching Hospitals, NHS Foundation Trust, Northern General Hospital
Sheffield, United Kingdom
July 30, 2021/by ehennesSt Antonius Hospital
Nieuwegein, Netherlands
August 2, 2021/by ehennesSt. Boniface Hospital
Winnipeg, Manitoba, Canada
April 21, 2022/by eallisonSt. Michael’s Hospital, Unity Health Toronto
Toronto, Ontario, Canada
August 2, 2021/by ehennesSt. Paul’s Hospital
Vancouver, British Columbia, Canada
April 21, 2022/by eallisonToronto General Hospital
Toronto, Ontario, Canada
August 2, 2021/by ehennesUniversitatsspital Basel Department of Cardiology
Basel, Switzerland
April 21, 2022/by eallisonUniversity Hospital Antwerp Cardiology Department – Clinical Trials
Edegem, Belgium
August 2, 2021/by eallisonUniversity Hospital Leuven, Universitair Ziekenhuis Leuven Dienst Bloedings- en Vaatziekten
Leuven, Belgium
August 2, 2021/by eallisonUniversity of Florida Health, Jacksonville
Jacksonville, Florida
July 14, 2021/by eallisonUniversity of Iowa Hospitals and Clinics
Iowa City, Iowa
July 14, 2021/by eallisonUniversity of Kentucky
Lexington, Kentucky
July 30, 2021/by eallisonUniversity of Ottawa Heart Institute
Ottawa, Ontario, Canada
August 2, 2021/by ehennesUniversity of Toronto
Toronto, Canada
July 14, 2021/by eallisonYork PCI Group, Inc.
Newmarket, Ontario, Canada
August 2, 2021/by ehennesZiekenhuis Oost-Limburg Study Center Intensive Care
Genk, Limburg, Belgium
August 2, 2021/by eallison